Carbetocin

Carbetocin is a synthetic long-acting oxytocin analog with agonist properties. It binds to oxytocin receptors on uterine smooth muscle, inducing rhythmic contractions of the uterus. It increases the frequency and tension of uterine contractions, thereby preventing and treating postpartum hemorrhage. Additionally, it acts on myoepithelial cells surrounding mammary alveoli, causing them to contract and promote milk flow from the alveoli into the milk ducts, facilitating breastfeeding.

Clinical Uses:

Prevention of Postpartum Hemorrhage:

This is one of the primary clinical uses of carbetocin. Administered via intramuscular or intravenous injection after cesarean section or vaginal delivery, it effectively promotes uterine contractions, reduces uterine bleeding, and lowers the risk of postpartum hemorrhage, ensuring maternal safety.

Induction and Augmentation of Labor:

In cases where early termination of pregnancy or enhanced uterine contractions are needed to facilitate delivery (e.g., post-term pregnancy, fetal distress), carbetocin can be used for labor induction and augmentation. It helps initiate or strengthen uterine contractions, advancing the labor process.