Caerulein
English Name: Caerulein
CAS Number: 56712 - 06 - 4
Molecular Formula: C₅₅H₇₄N₁₄O₁₅S₂
Molecular Weight: 1243.37
Amino Acid Sequence: pGlu - Gln - Asp - Tyr(SO₃H) - Thr - Gly - Trp - Met - Asp - Phe - NH₂
Appearance: White or off - white powder
Solubility: Soluble in polar solvents such as water and methanol
Stability: Relatively stable at room temperature, but may degrade or denature under conditions of high temperature, strong acids, or strong alkalis.
Caerulein can stimulate the pancreas to secrete pancreatic juice and various digestive enzymes, such as pancreatic amylase, pancreatic lipase, and trypsin, which is beneficial for the digestion and absorption of food. It can promote the peristalsis of the gastrointestinal tract, enhance the emptying ability of the stomach and intestines, and regulate the motor function of the gastrointestinal tract, making the propulsion of food in the gastrointestinal tract smoother. Caerulein can cause gallbladder contraction and promote the discharge of bile, which helps with the digestion and absorption of fat. In the central nervous system, caerulein may act as a neurotransmitter or neuromodulator, participating in the regulation of physiological functions such as appetite, pain sensation, and body temperature.
By injecting caerulein and observing the secretory function of the pancreas, it can assist in the diagnosis of pancreatic diseases, such as chronic pancreatitis and pancreatic cystic fibrosis. It is used to examine the contraction function of the gallbladder and helps diagnose gallbladder diseases such as cholecystitis and gallstones. Caerulein can be used to treat symptoms such as indigestion, bloating, and constipation caused by insufficient gastrointestinal motility, promoting the peristalsis and emptying of the gastrointestinal tract.