Periodontitis and diabetes are two common chronic diseases that are interrelated.Diabetes is a risk factor for periodontitis,while periodontitis negatively impacts blood glucose control in diabetic patients.Recent studies have shown that vitamin K2 can prevent calcification of blood vessels and soft tissues,and this inhibitory effect is enhanced with increased intake of vitamin D and dietary calcium.Vitamin K2 and vitamin D3 have a synergistic effect in clinical practice,which can improve their respective metabolism and offer potential benefits for diabetic and periodontitis patients.
On October 6,2024,Aydogan et al.published a research paper titled“Vitamin D3 and Vitamin K2 Combined Therapy for Stages I-II Periodontitis in Diabetic Patients”in the journalOral Dis.The study selected 38 diabetic patients with periodontitis who were undergoing non-surgical periodontal treatment and randomly divided them into an experimental group and a control group.The experimental group was supplemented with 2000 IU of vitamin D3 and 11.25 µg of vitamin K2 daily,while the control group took a placebo.The study lasted for six months.Researchers recorded clinical periodontal parameters at baseline,three months,and six months after treatment and collected serum and gingival crevicular fluid(GCF)samples to measure biochemical indicators,using enzyme-linked immunosorbent assay(ELISA)for analysis.
The study results showed that the clinical periodontal parameters of both groups significantly decreased at three and six months after treatment.At six months,the serum 25(OH)D3 level in the experimental group was significantly higher than that in the control group(p=0.02).Compared with baseline and the control group at three months,the serum IL-1β level at six months also significantly decreased.
The study concluded that IL-1β plays an important role in inflammation and tissue destruction associated with periodontitis.It is also involved in the regulation of insulin secretion and may promote the apoptosis of pancreatic β-cells,leading to type 2 diabetes.The significant decrease in serum IL-1β level in this study,along with the significant improvement in periodontal pocket depth,alveolar bone loss,plaque index,and gingival inflammation(redness and bleeding),indicates that the combined intake of vitamin D3 and vitamin K2 offers additional benefits for periodontitis in diabetic patients.
The high prevalence of periodontitis and diabetes is particularly prominent in the middle-aged and elderly population.Studies have shown that the combined application of vitamin K2 and vitamin D3 not only offers potential benefits for diabetes and periodontitis but may also bring other health effects.Therefore,it is recommended to take vitamin K2 and vitamin D3 to improve overall health.
Reference:Aydogan T,Karsiyaka Hendek M,Unsal B,Çifci A,Varol H,Kisa U,Olgun E.Effects of D(3)K(2)With Periodontal Therapy in Diabetes Mellitus and Stage I-II Periodontitis Patients.Oral Dis.2024 Oct 6.doi:10.1111/odi.15147.Online ahead of print.
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